Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: the Vitality 90+ study.

doi:10.1016/j.exger.2008.10.006

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Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: the Vitality 90+ study.

Experimental gerontology - 1 Apr 2009

Jylhävä Juulia, Eklund Carita, Jylhä Marja, Hervonen Antti, Lehtimäki Terho, Karhunen Pekka, Hurme Mikko

Abstract excerpt

Ageing is characterized by chronic low-grade inflammation and the expected lifespan may be affected by several immunological and inflammatory mediators. In this study, we investigated whether the functional Tyr402His polymorphism (rs1061170) on complement factor H (CFH) gene, which is a key inflammatory downregulator, modulates the longevity of 491 nonagenarians in the Vitality 90+ study. Logistic regression...

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PMID: 19000922
DOI: 10.1016/j.exger.2008.10.006

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Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: the Vitality 90+ study.PMID 19000922Read ↗

Complement Factor H polymorphism Y402H associates with inflammation, visual acuity, and cardiovascular mortality in the elderly population at large.Semantic proximity Read ↗

A common polymorphism in the complement factor H gene is associated with increased risk of myocardial infarction: the Rotterdam Study.Semantic proximity Read ↗

Complement factor H Y402H polymorphism results in diminishing CD4+ T cells and increasing C-reactive protein in plasma.Semantic proximity Read ↗

Usefulness of combining complement factor H and C-reactive protein genetic profiles for predicting myocardial infarction (from the Rotterdam Study).Semantic proximity Read ↗

Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in miceSemantic proximity Read ↗

Complement factor H Y402H decreases cardiovascular disease risk in patients with familial hypercholesterolaemia.Semantic proximity Read ↗

Complement factor H (Y402H) polymorphism and risk of coronary heart disease in US men and women.Semantic proximity Read ↗

The rs2516839 variation of USF1 gene is associated with 4-year mortality of nonagenarian women: The Vitality 90+ study.Semantic proximity Read ↗

Complement regulation at necrotic cell lesions is impaired by the age-related macular degeneration-associated factor-H His402 risk variant.Semantic proximity Read ↗

Cigarette smoking strongly modifies the association of complement factor H variant and the risk of lung cancer.Semantic proximity Read ↗

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Complement factor H Y402H gene polymorphism and coronary heart disease susceptibility: a meta-analysis.Semantic proximity Read ↗

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