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Article

Complement factor H Y402H decreases cardiovascular disease risk in patients with familial hypercholesterolaemia.

European heart journal - 1 Mar 2009

Koeijvoets Kristel C M C, Mooijaart Simon P, Dallinga-Thie Geesje M, Defesche Joep C, Steyerberg Ewout W, Westendorp Rudi G J, Kastelein John J P, van Hagen P Martin, Sijbrands Eric J G

Abstract excerpt

AIMS: Activation of the complement system seems an important link between inflammation and atherogenesis. The Y402H polymorphism of complement factor H (CFH) has been associated with cardiovascular events, but results are conflicting and possibly modified by age of onset of cardiovascular disease (CVD). METHODS AND RESULTS: We determined whether or not the Y402H polymorphism influenced CVD risk in a multicentre...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19098018
DOI: 10.1093/eurheartj/ehn568

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Complement factor H Y402H decreases cardiovascular disease risk in patients with familial hypercholesterolaemia.PMID 19098018Read ↗

Complement factor H (Y402H) polymorphism and risk of coronary heart disease in US men and women.Semantic proximity Read ↗

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Complement Factor H polymorphism Y402H associates with inflammation, visual acuity, and cardiovascular mortality in the elderly population at large.Semantic proximity Read ↗

Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals.Semantic proximity Read ↗

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Complement factor H Y402H polymorphism results in diminishing CD4+ T cells and increasing C-reactive protein in plasma.Semantic proximity Read ↗

Complement factor H Y402H gene polymorphism and coronary heart disease susceptibility: a meta-analysis.Semantic proximity Read ↗

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Complement factor H Y402H gene polymorphism, C-reactive protein, and risk of incident myocardial infarction, ischaemic stroke, and venous thromboembolism: a nested case-control study.Semantic proximity Read ↗

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