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Article

Association of the complement factor H Y402H polymorphism with cardiovascular disease is dependent upon hypertension status: The ARIC study.

American journal of hypertension - 1 May 2008

Volcik Kelly A, Ballantyne Christie M, Braun Michael C, Coresh Josef, Mosley Thomas H, Boerwinkle Eric

Abstract excerpt

BACKGROUND: Complement factor H (CFH) is a plasma protein that is essential in the regulation of the alternative complement pathway and has been implicated as taking part in complement inhibition in atherogenesis. We evaluated the association of the Y402H polymorphism with incident coronary heart disease (CHD), incident ischemic stroke, and carotid artery wall thickness (intima-media thickness (IMT)) in the...

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Source

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Identifiers

PMID: 18292760
DOI: 10.1038/ajh.2007.81
PMCID: PMC2674647

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of the complement factor H Y402H polymorphism with cardiovascular disease is dependent upon hypertension status: The ARIC study.PMID 18292760Read ↗

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Usefulness of combining complement factor H and C-reactive protein genetic profiles for predicting myocardial infarction (from the Rotterdam Study).Semantic proximity Read ↗

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Complement Factor H polymorphism Y402H associates with inflammation, visual acuity, and cardiovascular mortality in the elderly population at large.Semantic proximity Read ↗

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