Cigarette smoking strongly modifies the association of complement factor H variant and the risk of lung cancer.

doi:10.1016/j.canep.2011.11.004

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Cigarette smoking strongly modifies the association of complement factor H variant and the risk of lung cancer.

Cancer epidemiology - 1 Apr 2012

Zhang Zhi, Yu Dianke, Yuan Juxiang, Guo Yongli, Wang Hongge, Zhang Xuemei

Abstract excerpt

The complement system is an important immunosurveillance mechanism against tumors, and complement factor H (CFH) is a key regulator for activation of the complement system. Expression of complement factor H has been demonstrated in cell lines from several malignancies. In this study we examined the contribution of the single-nucleotide polymorphism (SNP) Try402His (Y402H) (rs1061170) in the CFH gene to the risk...

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PMID: 22197220
DOI: 10.1016/j.canep.2011.11.004

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