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Article

Complement regulation at necrotic cell lesions is impaired by the age-related macular degeneration-associated factor-H His402 risk variant.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2011

Lauer Nadine, Mihlan Michael, Hartmann Andrea, Schlötzer-Schrehardt Ursula, Keilhauer Claudia, Scholl Hendrik P N, Charbel Issa Peter, Holz Frank, Weber Bernhard H F, Skerka Christine, Zipfel Peter F

Abstract excerpt

Age-related macular degeneration is a leading form of blindness in Western countries and is associated with a common SNP (rs 1061170/Y402H) in the Factor H gene, which encodes the two complement inhibitors Factor H and FHL1. However, the functional consequences of this Tyr(402) His exchange in domain 7 are not precisely defined. In this study, we show that the Tyr(402) His sequence variation affects Factor H...

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Share to C-Reactive Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Microscopy, Confocal

Share to Necrosis

Share to Protein Structure, Quaternary

Source

Identifiers

PMID: 21930971
DOI: 10.4049/jimmunol.1002488

Genes

FHL1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Complement regulation at necrotic cell lesions is impaired by the age-related macular degeneration-associated factor-H His402 risk variant.PMID 21930971Read ↗

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