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Article

Glycogen synthase kinase-3beta and tau genes interact in Alzheimer's disease.

Annals of neurology - 1 Oct 2008

Kwok John B J, Loy Clement T, Hamilton Gillian, Lau Edmond, Hallupp Marianne, Williams Julie, Owen Michael J, Broe G Anthony, Tang Nelson, Lam Linda, Powell John F, Lovestone Simon, Schofield Peter R

Abstract excerpt

OBJECTIVE: We examined the epistatic effect between haplotypes of glycogen synthase kinase-3beta (GSK3B) gene and microtubule-associated protein Tau (MAPT) gene in Alzheimer's disease (AD). METHODS: A genetic association study of three AD cohorts was made. Linear regression analyses were used to examine effects of MAPT polymorphisms on gene expression and alternative splicing. beta-Catenin levels and signaling...

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Source

Identifiers

PMID: 18991351
DOI: 10.1002/ana.21476

Genes

MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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