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Article

GSK3β Interactions with Amyloid Genes: An Autopsy Verification and Extension.

Neurotoxicity research - 1 Oct 2015

Hohman Timothy J, Chibnik Lori, Bush William S, Jefferson Angela L, De Jaeger Phillip L, Thornton-Wells Tricia A, Bennett David A, Schneider Julie A

Abstract excerpt

Glyocogen synthase kinase 3 (GSK3) plays an important role in the pathophysiology of Alzheimer's disease (AD) through the phosphorylation of tau. Recent work has suggested that GSK3β also plays a role in the amyloid pathway of AD through genetic interactions with APP and APBB2 on in vivo measures of amyloid. This project extends the previously identified genotype interactions to an autopsy measure of amyloid,...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26194614
DOI: 10.1007/s12640-015-9541-0
PMCID: PMC4625986

Genes

APBB2
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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