GSK3B polymorphisms alter transcription and splicing in Parkinson's disease.

doi:10.1002/ana.20691

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Article

GSK3B polymorphisms alter transcription and splicing in Parkinson's disease.

Annals of neurology - 1 Dec 2005

Kwok John B J, Hallupp Marianne, Loy Clement T, Chan Daniel K Y, Woo Jean, Mellick George D, Buchanan Daniel D, Silburn Peter A, Halliday Glenda M, Schofield Peter R

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disorder characterized by a combination of motor symptoms. We identified two functional single nucleotide polymorphisms in the glycogen synthase kinase-3beta gene (GSK3B). A promoter single nucleotide polymorphism (rs334558) is associated with transcriptional strength in vitro in which the T allele has greater activity. An intronic single nucleotide polymorphism...

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PMID: 16315267
DOI: 10.1002/ana.20691

Genes

MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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