Article
Association of GSK3B with Alzheimer disease and frontotemporal dementia.
Archives of neurology - 1 Oct 2008
Schaffer Barbara A J, Bertram Lars, Miller Bruce L, Mullin Kristina, Weintraub Sandra, Johnson Nancy, Bigio Eileen H, Mesulam Marsel, Wiedau-Pazos Martina, Jackson George R, Cummings Jeffrey L, Cantor Rita M, Levey Allan I, Tanzi Rudolph E, Geschwind Daniel H
Abstract excerpt
BACKGROUND: Deposits of abnormally hyperphosphorylated tau are a hallmark of several dementias, including Alzheimer disease (AD), and about 10% of familial frontotemporal dementia (FTD) cases are caused by mutations in the tau gene. As a known tau kinase, GSK3B is a promising candidate gene in the remaining cases of FTD and in AD, for which tau mutations have not been found. OBJECTIVE: To examine the promoter of...
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