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Article

BDNF Val66Met polymorphism is associated with HPA axis reactivity to psychological stress characterized by genotype and gender interactions.

Psychoneuroendocrinology - 1 Apr 2009

Shalev Idan, Lerer Elad, Israel Salomon, Uzefovsky Florina, Gritsenko Inga, Mankuta David, Ebstein Richard P, Kaitz Marsha

Abstract excerpt

BACKGROUND: A key protein in maintaining neuronal integrity throughout the life span is brain-derived neurotrophic factor (BDNF). The BDNF gene is characterized by a functional polymorphism, which has been associated with stress-related disorders such as anxiety-related syndromes and depression, prompting us to examine individual responses by Genotype and Sex to a standardized social stress paradigm. Gender...

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Source

Identifiers

PMID: 18990498
DOI: 10.1016/j.psyneuen.2008.09.017

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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BDNF Val66Met polymorphism is associated with HPA axis reactivity to psychological stress characterized by genotype and gender interactions.PMID 18990498Read ↗

The BDNF Val66Met polymorphism affects HPA-axis reactivity to acute stress.Semantic proximity Read ↗

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Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism affects sympathetic tone in a gender-specific way.Semantic proximity Read ↗

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Increase in serum brain-derived neurotrophic factor in met allele carriers of the BDNF Val66Met polymorphism is specific to males.Semantic proximity Read ↗

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Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants.Semantic proximity Read ↗

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