Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BDNF val(66)met genotype shows distinct associations with the acoustic startle reflex and the cortisol stress response in young adults and children.

Psychoneuroendocrinology - 1 Apr 2016

Armbruster Diana, Müller-Alcazar Anett, Strobel Alexander, Lesch Klaus-Peter, Kirschbaum Clemens, Brocke Burkhard

Abstract excerpt

Brain Derived Neurotrophic Factor (BDNF) is a crucial regulator of neuronal development, organization and function and the val(66)met polymorphism in the BDNF gene has been associated with several (endo-) phenotypes of cognitive and affective processing. The BDNF met allele is considered a risk factor for anxiety and fear related phenotypes although findings are not entirely consistent. Here, the impact of BDNF...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acoustic Stimulation
Share to Amino Acid Substitution

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Brain-Derived Neurotrophic Factor

Share to Hydrocortisone

Share to Methionine

Share to Reflex, Startle

Share to Stress, Psychological

Share to Valine

Source

Identifiers

PMID: 26773399
DOI: 10.1016/j.psyneuen.2015.12.020

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BDNF val(66)met genotype shows distinct associations with the acoustic startle reflex and the cortisol stress response in young adults and children.PMID 26773399Read ↗

BDNF Val66Met polymorphism is associated with HPA axis reactivity to psychological stress characterized by genotype and gender interactions.Semantic proximity Read ↗

Genetics of human startle reactivity: A systematic review to acquire targets for an anxiety endophenotype.Semantic proximity Read ↗

The BDNF Val66Met polymorphism affects HPA-axis reactivity to acute stress.Semantic proximity Read ↗

BDNF Val66Met polymorphism is associated with higher anticipatory cortisol stress response, anxiety, and alcohol consumption in healthy adults.Semantic proximity Read ↗

Variant brain-derived neurotrophic factor Val66Met endophenotypes: implications for posttraumatic stress disorder.Semantic proximity Read ↗

Interaction between 5-HTTLPR and BDNF Val66Met polymorphisms on HPA axis reactivity in preschoolers.Semantic proximity Read ↗

The BDNF Val66Met polymorphism affects amygdala activity in response to emotional stimuli: evidence from a genetic imaging study.Semantic proximity Read ↗

BDNF and Cortisol integrative system – Plasticity vs. degeneration: Implications of the Val66Met polymorphismSemantic proximity Read ↗

The Val66Met brain-derived neurotrophic factor gene variant interacts with early pain exposure to predict cortisol dysregulation in 7-year-old children born very preterm: Implications for cognition.Semantic proximity Read ↗

BDNF Val 66 Met and 5-HTTLPR genotype moderate the impact of early psychosocial adversity on plasma brain-derived neurotrophic factor and depressive symptoms: a prospective study.Semantic proximity Read ↗

The BDNF Val66Met polymorphism: relation to familiar risk of affective disorder, BDNF levels and salivary cortisol.Semantic proximity Read ↗

Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.