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Article

Promoter independence as a feature of most skin papillomas in SENCAR mice.

Cancer research - 1 Feb 1991

Aldaz C M, Conti C J, Chen A, Bianchi A, Walker S B, DiGiovanni J

Abstract excerpt

In the present study, the fate of individual papillomas induced by initiation-promotion on the backs of SENCAR mice was monitored after discontinuation of limited promoter treatment. Groups of 40 SENCAR mice each were initiated by a single topical application of 7,12-dimethylbenz[a]anthracene (DMBA) at 2, 1, 0.5, or 0.25 micrograms/mouse. Animals were promoted with 2 micrograms of...

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Source

Identifiers

PMID: 1899044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Promoter independence as a feature of most skin papillomas in SENCAR mice.PMID 1899044Read ↗

Only a subset of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin papillomas are promotable by benzoyl peroxide.Semantic proximity Read ↗

Papillomas induced by initiation-promotion differ from those induced by carcinogen alone.Semantic proximity Read ↗

Topical retinoic acid reduces skin papilloma formation but resistant papillomas are at high risk for malignant conversion.Semantic proximity Read ↗

Further analysis of c-Ha-ras mutations in papillomas initiated by several polycyclic aromatic hydrocarbons and papillomas from uninitiated, promoter-treated skin in SENCAR mice.Semantic proximity Read ↗

Promotion of skin tumors by 12-O-tetradecanoylphorbol-13-acetate in two generations of descendants of male mice exposed to X-ray irradiation.Semantic proximity Read ↗

Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis.Semantic proximity Read ↗

SENCAR mouse skin tumors produced by promotion alone have A to G mutations in codon 61 of the c-rasHa gene.Semantic proximity Read ↗

New strains of inbred SENCAR mice with increased susceptibility to induction of papillomas and squamous cell carcinomas in skin.Semantic proximity Read ↗

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.Semantic proximity Read ↗

Overexpression of plasminogen activator inhibitor type 2 in basal keratinocytes enhances papilloma formation in transgenic mice.Semantic proximity Read ↗

Alterations in protein kinase C isozymes alpha and beta 2 in activated Ha-ras containing papillomas in the absence of an increase in diacylglycerol.Semantic proximity Read ↗

Evidence that mirex promotes a unique population of epidermal cells that cannot be distinguished by their mutant Ha-ras genotype.Semantic proximity Read ↗

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