Article
Evidence that mirex promotes a unique population of epidermal cells that cannot be distinguished by their mutant Ha-ras genotype.
Molecular carcinogenesis - 1 Sept 1997
Kim T W, Porter K L, Foley J F, Maronpot R R, Smart R C
Abstract excerpt
Mirex is a potent tumor promoter in 7,1 2-dimethylbenz[a]anthracene (DMBA)-initiated female CD-1 mouse skin. Like 12-O-tetradecanoylphorbol-13-acetate (TPA), mirex promotes papillomas that have a Ha-ras mutation; however, unlike TPA promotion, mirex promotion does not involve a general hyperplast...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- Bromodeoxyuridine
- Carcinogens
- Carcinoma, Squamous Cell
- Cell Division
- Cells, Cultured
- Cocarcinogenesis
- Female
- Genes, ras
- Genotype
- Immunohistochemistry
- Keratinocytes
- Mice
- Mice, Inbred BALB C
- Mirex
- Mutation
- Nitrosourea Compounds