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Article

Papillomas induced by initiation-promotion differ from those induced by carcinogen alone.

Nature - 1 Jan 2000

Reddy A L, Fialkow P J

Abstract excerpt

The discovery of a two-stage mechanism of carcinogenesis in mouse skin, with initiation and promotion as independent components, provided new approaches to the study of the development of neoplasms in experimental animals and humans. However, it is not clear how the carcinogen and promoting agent are involved at different steps in the development of papillomas and carcinomas. Here we have used cell markers in...

Topics

9,10-Dimethyl-1,2-benzanthracene
Animals
Carcinogens
Female
Genes
Mice
Neoplasms, Experimental
Papilloma
Phenotype
Phosphoglycerate Kinase
Skin Neoplasms
Tetradecanoylphorbol Acetate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

X Chromosome

Source

Identifiers

PMID: 6408484
DOI: 10.1038/304069a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6408484-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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