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SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease

11 Nov 2017

Abstract excerpt

Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Despite decades of study, effective treatments for AD are lacking. Mitochondrial dysfunction has been closely linked to the pathogenesis of AD, but the relationship between mitochondrial pathology and neuronal damage is poorly understood. Sirtuins (SIRT, silent mating type information regulation 2 homolog in yeast) are NAD-dependent histone...

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PMID: 29130578
DOI: 10.1111/acel.12679

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