Article

N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional relevance in Alzheimer disease

2025-10-03

Abstract excerpt

Neurodegenerative diseases like Alzheimer’s disease (AD) are characterized by progressive accumulation of pathological Tau proteins. Among the diverse Tau species, truncated variants are emerging as key contributors, yet their identity remains elusive, particularly for the N-terminal truncated ones. The present study identifies and characterizes a novel N-terminally truncated and N-alpha-acetylated form of the Tau...

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Literature Corpus work: fc1b248d-0aad-59d5-9626-1b4504419d44
DOI: 10.1101/2025.10.03.680200

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