Article

The transcription factor Rreb1 regulates epithelial architecture and invasiveness in gastrulating mouse embryos

2020-11-12

Abstract excerpt

Ras-responsive element-binding protein 1 (Rreb1) is a zinc-finger transcription factor downstream of RAS signaling. Rreb1 has been implicated in cancer but little is known about its role in mammalian non-disease states. Here, we found that Rreb1 is essential for mouse embryonic development. Loss of Rreb1 led to a reduction in the expression of vasculogenesis factors, cardiovascular defects and embryonic lethalit...

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Literature Corpus work: faff93d5-b110-5063-9014-e6ea41fc2771
DOI: 10.1101/2020.11.12.379578

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