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Article

Imaging target mRNA and siRNA-mediated gene silencing in vivo with ribozyme-based reporters.

Chembiochem : a European journal of chemical biology - 3 Nov 2008

So Min-Kyung, Gowrishankar Gayatri, Hasegawa Sumitaka, Chung June-Key, Rao Jianghong

Abstract excerpt

Noninvasive imaging of specific mRNAs in living subjects promises numerous biological and medical applications. Common strategies use fluorescently or radioactively labelled antisense probes to detect target mRNAs through a hybridization mechanism, but have met with limited success in living animals. Here we present a novel molecular imaging approach based on the group I intron of Tetrahymena thermophila for...

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PMID: 18972511
DOI: 10.1002/cbic.200800370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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