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Article

[Construction of a trans-splicing ribozyme for restoring EGFP truncation mutation].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology - 1 Sept 2005

Li Bing, Xiong Yu-Quan, Tu Hong-Bin, Liu Qi-Cai, Zou Dong-Ting, Zhou Wen-Qu, Chen Yao-Yong

Abstract excerpt

Special designed group I intron ribozymes can specifically splice objective RNA, repair the mutant gene in RNA level. The specificity of ribozyme is determined by nucleotides specific internal guide sequence (IGS) introduced to the enzyme. In this study, fragment sequence containing Tetrahymena thermophilia intron I of 26S rRNA gene was cloned and cis-splicing activity of this ribozyme was confirmed by in vitro...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16285516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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