Trans-splicing ribozymes for targeted gene delivery.

doi:10.1006/jmbi.1998.2447

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Article

Trans-splicing ribozymes for targeted gene delivery.

Journal of molecular biology - 5 Feb 1999

Köhler U, Ayre B G, Goodman H M, Haseloff J

Abstract excerpt

Ribozymes are potential tools for genetic manipulation, and various naturally occurring catalytic RNAs have been dissected and used as the basis for the design of new endoribonuclease activities. While such cleaving ribozymes may work well in vitro, they have not proved to be routinely effective...

Topics

Antiviral Agents
Base Sequence
Chloramphenicol O-Acetyltransferase
Cucumovirus
Cytomegalovirus
Escherichia coli
Gene Transfer Techniques
HIV-1
Molecular Biology
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
RNA Splicing
RNA, Antisense
RNA, Catalytic
RNA, Messenger
Recombinant Proteins
Substrate Specificity

Source

Open in PubMed

Identifiers

PMID: 9925776
DOI: 10.1006/jmbi.1998.2447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9925776-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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