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Article

Trans-splicing ribozymes for targeted gene delivery.

Journal of molecular biology - 5 Feb 1999

Köhler U, Ayre B G, Goodman H M, Haseloff J

Abstract excerpt

Ribozymes are potential tools for genetic manipulation, and various naturally occurring catalytic RNAs have been dissected and used as the basis for the design of new endoribonuclease activities. While such cleaving ribozymes may work well in vitro, they have not proved to be routinely effective in depleting living cells of the chosen target RNA. Recently, trans-splicing ribozymes have been employed to repair...

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Identifiers

PMID: 9925776
DOI: 10.1006/jmbi.1998.2447

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