Article
Inhibition of double-stranded RNA-dependent protein kinase PKR by vaccinia virus E3: role of complex formation and the E3 N-terminal domain.
Molecular and cellular biology - 1 Dec 1998
Romano P R, Zhang F, Tan S L, Garcia-Barrio M T, Katze M G, Dever T E, Hinnebusch A G
Abstract excerpt
The human double-stranded RNA (dsRNA)-dependent protein kinase PKR inhibits protein synthesis by phosphorylating translation initiation factor 2alpha (eIF2alpha). Vaccinia virus E3L encodes a dsRNA binding protein that inhibits PKR in virus-infected cells, presumably by sequestering dsRNA activat...
Topics
- Cell Division
- Dimerization
- Enzyme Inhibitors
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Mutation
- Phosphorylation
- Protein Binding
- RNA-Binding Proteins
- Recombinant Fusion Proteins
- Ribosomes
- Saccharomyces cerevisiae
- Viral Proteins
- eIF-2 Kinase