Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism.

doi:10.1096/fj.08-118976

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Article

Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2009

Yakar Shoshana, Rosen Clifford J, Bouxsein Mary L, Sun Hui, Mejia Wilson, Kawashima Yuki, Wu Yingjie, Emerton Kelly, Williams Valerie, Jepsen Karl, Schaffler Mitchell B, Majeska Robert J, Gavrilova Oksana, Gutierrez Mariana, Hwang David, Pennisi Patricia, Frystyk Jan, Boisclair Yves, Pintar John, Jasper Héctor, Domene Horacio, Cohen Pinchas, Clemmons David, LeRoith Derek

Abstract excerpt

Serum insulin-like growth factor (IGF) -1 is secreted mainly by the liver and circulates bound to IGF-binding proteins (IGFBPs), either as binary complexes or ternary complexes with IGFBP-3 or IGFBP-5 and an acid-labile subunit (ALS). The purpose of this study was to genetically dissect the role of IGF-1 circulatory complexes in somatic growth, skeletal integrity, and metabolism. Phenotypic comparisons of...

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Identifiers

PMID: 18952711
DOI: 10.1096/fj.08-118976
PMCID: PMC2653987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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