Insulin-like Growth Factors in Pediatric Health and Disease

Abstract excerpt

SINCE THE introduction of the somatomedin hypothesis by Daughaday et al. (1) almost a half-century ago, our understanding of the insulin-like growth factor (IGF) system has evolved considerably. This evolution, from one of a simple pituitary-dependent growth factor secreted from liver to a ubiquitous and complex family of ligands, receptors, and binding proteins, has been spurred by advances in both protein...

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