Article
Mouse models for understanding the growth hormone insulin-like growth factor-I axis.
Hormone research - 1 Jan 2007
Rosen Clifford J
Abstract excerpt
BACKGROUND: Mouse models that include spontaneous mutations, as well as those carrying allelic differences, have been extremely useful in clarifying the role of skeletal and circulating insulin-like growth factor I (IGF-I) in peak bone acquisition. The role of peroxisome proliferator-activated receptor gamma, a nuclear receptor and key differentiation factor for adipogenesis, has provided new insights into the...
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