Mouse models for understanding the growth hormone insulin-like growth factor-I axis.

Abstract excerpt

BACKGROUND: Mouse models that include spontaneous mutations, as well as those carrying allelic differences, have been extremely useful in clarifying the role of skeletal and circulating insulin-like growth factor I (IGF-I) in peak bone acquisition. The role of peroxisome proliferator-activated receptor gamma, a nuclear receptor and key differentiation factor for adipogenesis, has provided new insights into the...

Topics

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• Adipogenesis
• Bone and Bones
• Bone Marrow
• Insulin-Like Growth Factor I
• Models, Animal
• Osteogenesis