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Article

IGF-1 regulation of key signaling pathways in bone

2 Oct 2013

Abstract excerpt

Insulin-like growth factor 1 (IGF-1) is an unique peptide that functions in an endocrine/paracrine and autocrine manner in most tissues. Although it was postulated initially that liver-derived IGF-1 was the major source of IGF-1 (that is, the somatomedin hypothesis), it is also produced in a wide variety of tissues and can function in numerous ways as both a proliferative and differentiative factor. One such...

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PMID: 24422135
DOI: 10.1038/bonekey.2013.171

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