Article
Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5.
Molecular endocrinology (Baltimore, Md.) - 1 Sept 2006
Ning Yun, Schuller Alwin G P, Bradshaw Sheri, Rotwein Peter, Ludwig Thomas, Frystyk Jan, Pintar John E
Abstract excerpt
IGF-I and IGF-II are essential regulators of mammalian growth, development and metabolism, whose actions are modified by six high-affinity IGF binding proteins (IGFBPs). New lines of knockout (KO) mice lacking either IGFBP-3, -4, or -5 had no apparent deficiencies in growth or metabolism beyond a modest growth impairment (approximately 85-90% of wild type) when IGFBP-4 was eliminated. To continue to address the...
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