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Article

Binding protein-3-selective insulin-like growth factor I variants: engineering, biodistributions, and clearance.

Endocrinology - 1 Jan 2001

Dubaquié Y, Mortensen D L, Intintoli A, Hogue D A, Nakamura G, Rancatore P, Lester P, Sadick M D, Filvaroff E, Fielder P J, Lowman H B

Abstract excerpt

Insulin-like growth factor I (IGF-I) is a potent anabolic peptide that mediates most of its pleiotropic effects through association with the IGF type I receptor. Biological availability and plasma half-life of IGF-I are modulated by soluble binding proteins (IGFBPs), which sequester free IGF-I into high affinity complexes. Elevated levels of specific IGFBPs have been observed in several pathological conditions,...

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PMID: 11145579
DOI: 10.1210/endo.142.1.7864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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