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Article

Conditional Knockout of Mouse Insulin-Like Growth Factor-1 Gene Using the Cre/loxP System

1 Apr 2000

Abstract excerpt

Insulin-like growth factor-1 (IGF-1) is an essential growth factor for normal intrauterine development and postnatal growth. Mice with a complete deficiency of IGF-1 (IGF-1-null mice), created by homologous recombination, were found to exhibit postnatal lethality, growth retardation, infertility, and profound defects in the development of major organ systems. Furthermore, IGF-1-null mice were resistant to growth...

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PMID: 10721003
DOI: 10.1046/j.1525-1373.2000.22349.x

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