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Article

A model for the development of human IgD-only B cells: Genotypic analyses suggest their generation in superantigen driven immune responses.

Molecular immunology - 1 Feb 2009

Seifert Marc, Steimle-Grauer Susanne A, Goossens Tina, Hansmann Martin-Leo, Bräuninger Andreas, Küppers Ralf

Abstract excerpt

Human peripheral blood (PB) B cells expressing only IgD and tonsillar IgD-secreting plasma cells carry highly mutated V(H) genes and show preferential Iglambda usage. To further characterize these peculiar cells and gain insight into their generation, we analysed rearranged V(H) and V(L) genes of single IgD-only lambda(+) PB B cells and IgD(+) plasma cells from four individuals each. We demonstrate that the high...

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Source

Identifiers

PMID: 18952293
DOI: 10.1016/j.molimm.2008.07.032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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