Article
Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells.
The Journal of experimental medicine - 2 Nov 1998
Klein U, Rajewsky K, Küppers R
Abstract excerpt
Immunoglobulin (Ig)M+IgD+ B cells are generally assumed to represent antigen-inexperienced, naive B cells expressing variable (V) region genes without somatic mutations. We report here that human IgM+IgD+ peripheral blood (PB) B cells expressing the CD27 cell surface antigen carry mutated V genes...
Topics
- Adult
- B-Lymphocyte Subsets
- B-Lymphocytes
- Biomarkers
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Genes, Immunoglobulin
- Humans
- Immunoglobulin D
- Immunoglobulin M
- Immunoglobulin Variable Region
- Immunologic Memory
- Mutation
- Tumor Necrosis Factor Receptor Superfamily, Member 7