Article
CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans.
Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2001
Weller S, Faili A, Garcia C, Braun M C, Le Deist F F, de Saint Basile G G, Hermine O, Fischer A, Reynaud C A, Weill J C
Abstract excerpt
Somatically mutated IgM(+)-only and IgM(+)IgD(+)CD27(+) B lymphocytes comprise approximately 25% of the human peripheral B cell pool. These cells phenotypically resemble class-switched B cells and have therefore been classified as postgerminal center memory B cells. X-linked hyper IgM patients have a genetic defect characterized by a mutation of the CD40L gene. These patients, who do not express a functional CD40...
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