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Article

Anti-CD40 plus interleukin-4-activated human naive B cell lines express unmutated immunoglobulin genes with intraclonal heavy chain isotype variability.

European journal of immunology - 1 Mar 1995

Galibert L, van Dooren J, Durand I, Rousset F, Jefferis R, Banchereau J, Lebecque S

Abstract excerpt

Combination of anti-CD40 antibody and interleukin-4 (IL-4) induces B cell clonal expansion reminiscent of the T-dependent proliferation following antigenic challenge in vivo. We have analyzed the usage of CH genes and the presence or absence of somatic mutations within the progeny of a single hum...

Topics

Antibodies, Anti-Idiotypic
Antibodies, Monoclonal
Antigens, CD
Antigens, Differentiation, B-Lymphocyte
B-Lymphocytes
Base Sequence
CD40 Antigens
Cells, Cultured
Genes, Immunoglobulin
Humans
Immunoglobulin Class Switching

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Heavy Chains

Interleukin-4

Lymphocyte Activation

Molecular Sequence Data

Mutation

Source

Identifiers

PMID: 7535701
DOI: 10.1002/eji.1830250316

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7535701-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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