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Article

Promoter polymorphisms in ACE (angiotensin I-converting enzyme) associated with clinical outcomes in hypertension.

Clinical pharmacology and therapeutics - 1 Jan 2009

Johnson A D, Gong Y, Wang D, Langaee T Y, Shin J, Cooper-Dehoff R M, Schork N J, Binkley P, Pepine C J, Johnson J A, Sadee W

Abstract excerpt

Genetic variants of ACE are suspected risk factors in cardiovascular disease, but the alleles responsible for the variations remain unidentified. To search for regulatory polymorphisms, allelic angiotensin I-converting enzyme (ACE) mRNA expression was measured in 65 heart tissues, followed by genotype scanning of the ACE locus. Marked allelic expression imbalance (AEI) detected in five African-American subjects...

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Identifiers

PMID: 18946466
DOI: 10.1038/clpt.2008.194
PMCID: PMC2709290

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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