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Article

CACNA1C gene polymorphisms, cardiovascular disease outcomes, and treatment response.

Circulation. Cardiovascular genetics - 1 Aug 2009

Beitelshees Amber L, Navare Hrishikesh, Wang Danxin, Gong Yan, Wessel Jennifer, Moss James I, Langaee Taimour Y, Cooper-DeHoff Rhonda M, Sadee Wolfgang, Pepine Carl J, Schork Nicolas J, Johnson Julie A

Abstract excerpt

BACKGROUND: The gene encoding the target of calcium channel blockers, the alpha1c-subunit of the L-type calcium channel (CACNA1C), has not been well characterized, and only small pharmacogenetic studies testing this gene have been published to date. METHODS AND RESULTS: Resequencing of CACNA1C was performed followed by a nested case-control study of the INternational VErapamil SR/trandolapril STudy (INVEST)...

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Identifiers

PMID: 20031608
DOI: 10.1161/CIRCGENETICS.109.857839
PMCID: PMC2761685

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