Article
Association of angiotensinogen gene polymorphisms with essential hypertension in African-Americans and Caucasians.
Human heredity - 1 Jan 2005
Markovic Daniela, Tang Xiagna, Guruju Mallikarjunrao, Levenstien Mark A, Hoh Josephine, Kumar Ashok, Ott Jurg
Abstract excerpt
OBJECTIVE: Molecular variants of angiotensinogen (AGT) have been linked to essential hypertension, and promoter variants have been shown to alter the transcription rate of AGT in vitro. We employed a case-control study to determine whether single nucleotide polymorphisms (SNPs) in the promoter region of AGT were associated with hypertension in African-Americans and Caucasians. METHODS: The frequencies of the...
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