Article
Altered beta-2 adrenergic receptor gene expression in human clinical hypertension.
Biological research for nursing - 1 Jul 2009
Dungan Jennifer R, Conley Yvette P, Langaee Taimour Y, Johnson Julie A, Kneipp Shawn M, Hess Philip J, Yucha Carolyn B
Abstract excerpt
OBJECTIVES: The beta-2 adrenergic receptor is involved in mediating vasodilatation via neurohumoral and sympathetic nervous system pathways. Alterations in beta-2 adrenergic receptor gene expression (mRNA transcription) may contribute to the hypertensive phenotype. Human gene expression in clinical phenotypes remains largely unexplored due to ethical constraints involved in obtaining human tissue. We devised a...
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