Article
Angiotensinogen promoter sequence variants in essential hypertension.
American journal of hypertension - 1 Dec 2006
Velez Digna R, Guruju Mallikarjunrao, Vinukonda Govindaiah, Prater Alicia, Kumar Ashok, Williams Scott M
Abstract excerpt
BACKGROUND: Essential hypertension is a complex multifactorial disease caused by ill-defined genetic factors. The angiotensinogen (AGT) gene has been implicated as a risk factor in essential hypertension. METHODS: To assess the role of AGT in hypertension, we evaluated two polymorphisms (A-6G and C-20A) in the 5' region of the gene that have been shown to have a role in transcriptional regulation. A total of 463...
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