Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial.

doi:10.1097/HJH.0b013e3282b9720e

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Article

Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial.

Journal of hypertension - 1 Oct 2007

Bhatnagar Vibha, O'Connor Daniel T, Schork Nicholas J, Salem Rany M, Nievergelt Caroline M, Rana Brinda K, Smith Douglas W, Bakris George L, Middleton John P, Norris Keith C, Wright Jackson T, Cheek Deanna, Hiremath Leena, Contreras Gabriel, Appel Lawrence J, Lipkowitz Michael S

Abstract excerpt

OBJECTIVE: It has yet to be determined whether genotyping at the angiotensin-converting enzyme (ACE) locus is predictive of blood pressure response to an ACE inhibitor. METHODS: Participants from the African American Study of Kidney Disease and Hypertension trial randomized to the ACE inhibitor ramipril (n = 347) were genotyped at three polymorphisms on ACE, just downstream from the ACE insertion/deletion...

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PMID: 17885551
DOI: 10.1097/HJH.0b013e3282b9720e
PMCID: PMC2792638

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