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Article

P18 is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma development.

International journal of cancer - 15 Jan 2009

van Veelen Wendy, Klompmaker Rob, Gloerich Martijn, van Gasteren Carola J R, Kalkhoven Eric, Berger Ruud, Lips Cornelis J M, Medema Rene H, Höppener Jo W M, Acton Dennis S

Abstract excerpt

In multiple endocrine neoplasia syndrome Type 2 (MEN2), medullary thyroid carcinoma (MTC) and pheochromocytoma (PC) are associated with hereditary activating germ-line mutations in the RET proto-oncogene. Also in a large percentage of sporadic MTCs and PCs, somatic RET mutations appear to be involved in tumor formation. In one single MEN2 family an extensive variety in disease expression may be observed,...

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Share to Carcinoma, Medullary
Share to Cyclin-Dependent Kinase Inhibitor p18

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Tumor Suppressor

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Share to Sequence Homology, Amino Acid

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Source

Identifiers

PMID: 18942719
DOI: 10.1002/ijc.23977

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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P18 is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma development.PMID 18942719Read ↗

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