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Article

Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme.

Cancer research - 15 Apr 2008

Solomon David A, Kim Jung-Sik, Jenkins Sultan, Ressom Habtom, Huang Michael, Coppa Nicholas, Mabanta Lauren, Bigner Darell, Yan Hai, Jean Walter, Waldman Todd

Abstract excerpt

Genomic alterations leading to aberrant activation of cyclin/cyclin-dependent kinase (cdk) complexes drive the pathogenesis of many common human tumor types. In the case of glioblastoma multiforme (GBM), these alterations are most commonly due to homozygous deletion of p16(INK4a) and less commonly due to genomic amplifications of individual genes encoding cyclins or cdks. Here, we describe deletion of the...

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Identifiers

PMID: 18381405
DOI: 10.1158/0008-5472.CAN-07-6388
PMCID: PMC4394609

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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