Expression of p18(INK4C) is down-regulated in human pituitary adenomas.

doi:10.1007/s12022-009-9076-0

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Article

Expression of p18(INK4C) is down-regulated in human pituitary adenomas.

Endocrine pathology - 1 Jan 2009

Hossain M Golam, Iwata Takeo, Mizusawa Noriko, Qian Zhi Rong, Shima Shahidan Wan Nazatul, Okutsu Toru, Yamada Shozo, Sano Toshiaki, Yoshimoto Katsuhiko

Abstract excerpt

Cyclin-dependent kinase inhibitors represented by the INK4 family comprising p16(INK4A), p15(INK4B), p18(INK4C), and p19(INK4D) are regulators of the cell cycle shown to be aberrant in many types of cancer. Mice lacking p18(Ink4c) exhibit a series of phenotypes including the development of widespread organomegaly and pituitary adenomas. The objective of our study is to examine the role of p18(INK4C) in the...

Topics

Adenoma
Adult
Aged
Aged, 80 and over
Cyclin-Dependent Kinase Inhibitor p18
DNA Methylation
Down-Regulation
Female
Gene Expression Regulation, Neoplastic
Humans
Male
Middle Aged
Mutation
Pituitary Neoplasms
RNA, Messenger

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PMID: 19401813
DOI: 10.1007/s12022-009-9076-0

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