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Article

Synergistic effect of oncogenic RET and loss of p18 on medullary thyroid carcinoma development.

Cancer research - 1 Mar 2008

van Veelen Wendy, van Gasteren Carola J R, Acton Dennis S, Franklin David S, Berger Ruud, Lips Cornelis J M, Höppener Jo W M

Abstract excerpt

Activating mutations in the RET proto-oncogene are associated with both familial and sporadic medullary thyroid carcinoma (MTC) development; however, the genetic mechanisms underlying MTC tumorigenesis remain largely unknown. Recently, we have identified somatic inactivating mutations in the cell cycle inhibitor gene P18 in human MTC, which coincided with activating RET mutations, suggesting a role for loss of...

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Source

Identifiers

PMID: 18316595
DOI: 10.1158/0008-5472.CAN-07-5754

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Synergistic effect of oncogenic RET and loss of p18 on medullary thyroid carcinoma development.PMID 18316595Read ↗

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