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Article

p18Ink4c, but not p27Kip1, collaborates with Men1 to suppress neuroendocrine organ tumors.

Molecular and cellular biology - 1 Feb 2007

Bai Feng, Pei Xin-Hai, Nishikawa Toru, Smith Matthew D, Xiong Yue

Abstract excerpt

Mutant mice lacking both cyclin-dependent kinase (CDK) inhibitors p18(Ink4c) and p27(Kip1) develop a tumor spectrum reminiscent of human multiple endocrine neoplasia (MEN) syndromes. To determine how p18 and p27 genetically interact with Men1, the tumor suppressor gene mutated in familial MEN1, we characterized p18-Men1 and p27-Men1 double mutant mice. Compared with their corresponding single mutant littermates,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 17145768
DOI: 10.1128/MCB.01764-06
PMCID: PMC1800728

Genes

CDK2
CDK4
MEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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p18Ink4c, but not p27Kip1, collaborates with Men1 to suppress neuroendocrine organ tumors.PMID 17145768Read ↗

p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers.Semantic proximity Read ↗

MEN-4 and other multiple endocrine neoplasias due to cyclin-dependent kinase inhibitors (p27(Kip1) and p18(INK4C)) mutations.Semantic proximity Read ↗

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Functional Collaboration between Different Cyclin-Dependent Kinase Inhibitors Suppresses Tumor Growth with Distinct Tissue SpecificitySemantic proximity Read ↗

p27kip1: a new multiple endocrine neoplasia gene?Semantic proximity Read ↗

Genetic evidence for functional dependency of p18Ink4c on Cdk4.Semantic proximity Read ↗

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