Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p18<sup><i>Ink4c</i></sup> and <i>Pten</i> Constrain a Positive Regulatory Loop between Cell Growth and Cell Cycle Control

1 Jun 2006

Abstract excerpt

Inactivation of the Rb-mediated G1 control pathway is a common event found in many types of human tumors. To test how the Rb pathway interacts with other pathways in tumor suppression, we characterized mice with mutations in both the cyclin-dependent kinase (CDK) inhibitor p18 Ink4c and the lipid phosphatase Pten, which regulates cell growth. The double mutant mice develop a wider spectrum of tumors, including...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Cancer-related Molecular Pathways
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16738322
DOI: 10.1128/mcb.00266-06

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p18<sup><i>Ink4c</i></sup> and <i>Pten</i> Constrain a Positive Regulatory Loop between Cell Growth and Cell Cycle ControlPMID 16738322Read ↗

Expression of p16Ink4a Compensates for <i>p18Ink4c</i> Loss in Cyclin-Dependent Kinase 4/6–Dependent Tumors and TissuesSemantic proximity Read ↗

Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis.Semantic proximity Read ↗

p18Ink4c, but not p27Kip1, collaborates with Men1 to suppress neuroendocrine organ tumors.Semantic proximity Read ↗

Genetic evidence for functional dependency of p18Ink4c on Cdk4.Semantic proximity Read ↗

Distinct versus redundant properties among members of the INK4 family of cyclin‐dependent kinase inhibitorsSemantic proximity Read ↗

p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers.Semantic proximity Read ↗

<i>Lkb1</i> Deficiency Causes Prostate Neoplasia in the MouseSemantic proximity Read ↗

<i>Pten</i> Deficiency Activates Distinct Downstream Signaling Pathways in a Tissue-Specific MannerSemantic proximity Read ↗

<i>INK4d</i>-Deficient Mice Are Fertile Despite Testicular AtrophySemantic proximity Read ↗

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of PtenSemantic proximity Read ↗

Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity.Semantic proximity Read ↗

Loss of PI5P4Kα Slows the Progression of a Pten Mutant Basal Cell Model of Prostate Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.