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Article

Genomic Modifiers of Natural Killer Cells, Immune Responsiveness and Lymphoid Tissue Remodeling Together Increase Host Resistance to Viral Infection.

PLoS pathogens - 1 Feb 2016

Gillespie Alyssa Lundgren, Teoh Jeffrey, Lee Heather, Prince Jessica, Stadnisky Michael D, Anderson Monique, Nash William, Rival Claudia, Wei Hairong, Gamache Awndre, Farber Charles R, Tung Kenneth, Brown Michael G

Abstract excerpt

The MHC class I D(k) molecule supplies vital host resistance during murine cytomegalovirus (MCMV) infection. Natural killer (NK) cells expressing the Ly49G2 inhibitory receptor, which specifically binds D(k), are required to control viral spread. The extent of D(k)-dependent host resistance, however, differs significantly amongst related strains of mice, C57L and MA/My. As a result, we predicted that relatively...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26845690
DOI: 10.1371/journal.ppat.1005419
PMCID: PMC4742223

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