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Article

Transgenic expression of the activating natural killer receptor Ly49H confers resistance to cytomegalovirus in genetically susceptible mice.

The Journal of experimental medicine - 17 Feb 2003

Lee Seung-Hwan, Zafer Ahmed, de Repentigny Yves, Kothary Rashmi, Tremblay Michel L, Gros Philippe, Duplay Pascale, Webb John R, Vidal Silvia M

Abstract excerpt

Natural resistance to infection with mouse cytomegalovirus (MCMV) is controlled by a dominant locus, Cmv1. Cmv1 is linked to the Ly49 family of natural killer receptors on distal chromosome 6. While some studies localized Cmv1 as distal to the Ly49 gene cluster, genetic and functional analysis identified Ly49h as a pivotal factor in resistance to MCMV. The role of these two independent genomic domains in MCMV...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Herpesviridae Infections

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Share to Lectins, C-Type

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Source

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Identifiers

PMID: 12591908
DOI: 10.1084/jem.20021713
PMCID: PMC2193863

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transgenic expression of the activating natural killer receptor Ly49H confers resistance to cytomegalovirus in genetically susceptible mice.PMID 12591908Read ↗

Ly49h is necessary for genetic resistance to murine cytomegalovirus.Semantic proximity Read ↗

Ly49h-deficient C57BL/6 mice: a new mouse cytomegalovirus-susceptible model remains resistant to unrelated pathogens controlled by the NK gene complex.Semantic proximity Read ↗

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Specific dysregulation of IFNγ production by natural killer cells confers susceptibility to viral infection.Semantic proximity Read ↗

Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily.Semantic proximity Read ↗

Innate immunity to cytomegalovirus: the Cmv1 locus and its role in natural killer cell function.Semantic proximity Read ↗

The Cmv1 host resistance locus is closely linked to the Ly49 multigene family within the natural killer cell gene complex on mouse chromosome 6.Semantic proximity Read ↗

Viral MHC class I-like molecule allows evasion of NK cell effector responses in vivo.Semantic proximity Read ↗

Cmv1 and natural killer cell responses to murine cytomegalovirus infection.Semantic proximity Read ↗

Use of inbred mouse strains to map recognition receptors of MCMV infected cells in the NK cell gene locus.Semantic proximity Read ↗

Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell ReceptorsSemantic proximity Read ↗

Genetic mapping of Cmv1 in the region of mouse chromosome 6 encoding the NK gene complex-associated loci Ly49 and musNKR-P1.Semantic proximity Read ↗

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