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Article

Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily.

Nature genetics - 1 May 2001

Lee S H, Girard S, Macina D, Busà M, Zafer A, Belouchi A, Gros P, Vidal S M

Abstract excerpt

Cytomegalovirus is the leading cause of congenital viral disease and the most important opportunistic infection in immunocompromised patients. We have used a mouse experimental infection model (MCMV) to study the genetic parameters of host/virus interaction. Susceptibility to infection with MCMV is controlled by Cmv1, a chromosome 6 locus that regulates natural killer (NK) cell activity against virally infected...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11326273
DOI: 10.1038/ng0501-42

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily.PMID 11326273Read ↗

The Cmv1 host resistance locus is closely linked to the Ly49 multigene family within the natural killer cell gene complex on mouse chromosome 6.Semantic proximity Read ↗

Use of inbred mouse strains to map recognition receptors of MCMV infected cells in the NK cell gene locus.Semantic proximity Read ↗

Genetic mapping of Cmv1 in the region of mouse chromosome 6 encoding the NK gene complex-associated loci Ly49 and musNKR-P1.Semantic proximity Read ↗

Ly49h is necessary for genetic resistance to murine cytomegalovirus.Semantic proximity Read ↗

Innate immunity to cytomegalovirus: the Cmv1 locus and its role in natural killer cell function.Semantic proximity Read ↗

High-resolution linkage map in the proximity of the host resistance locus Cmv1.Semantic proximity Read ↗

Genomic Modifiers of Natural Killer Cells, Immune Responsiveness and Lymphoid Tissue Remodeling Together Increase Host Resistance to Viral Infection.Semantic proximity Read ↗

A 2-Mb YAC contig and physical map of the natural killer gene complex on mouse chromosome 6.Semantic proximity Read ↗

The major locus for mouse adenovirus susceptibility maps to genes of the hematopoietic cell surface-expressed LY6 family.Semantic proximity Read ↗

Cmv1 and natural killer cell responses to murine cytomegalovirus infection.Semantic proximity Read ↗

Ly49h-deficient C57BL/6 mice: a new mouse cytomegalovirus-susceptible model remains resistant to unrelated pathogens controlled by the NK gene complex.Semantic proximity Read ↗

Localization on a physical map of the NKC-linked Cmv1 locus between Ly49b and the Prp gene cluster on mouse chromosome 6.Semantic proximity Read ↗

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