Article
HLA class II genes in precision-based care of childhood diseases: what we can learn from celiac disease.
Pediatric research - 1 Jan 2021
Del Pozzo Giovanna, Farina Federica, Picascia Stefania, Laezza Mariavittoria, Vitale Serena, Gianfrani Carmen
Abstract excerpt
Celiac disease (CeD) is a chronic immuno-mediated enteropathy caused by dietary gluten with marked autoimmunity traits. The human leukocyte antigen (HLA) class II heterodimers represent the main predisposing factor, although environmental agents, as viral infection, gut microbiota, and dietary regimen, also contribute to CeD risk. These molecules are involved in autoimmunity as they present self-antigens to...
Topics
- Celiac Disease
- Clinical Decision-Making
- Diet, Gluten-Free
- Early Diagnosis
- Genes, MHC Class II
- Genetic Predisposition to Disease
- Genetic Testing
- Glutens
- HLA-DQ Antigens
- Humans
- Phenotype