The involvement of the HLA-DQB1 alleles in the risk and the severity of Iranian coeliac disease patients.

doi:10.1111/iji.12128

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Article

The involvement of the HLA-DQB1 alleles in the risk and the severity of Iranian coeliac disease patients.

International journal of immunogenetics - 1 Aug 2014

Zamani M, Modares-Sadegi M, Shirvani F, Zamani H, Emami M H

Abstract excerpt

Coeliac disease (CD) is a highly prevalent autoimmune disorder that is triggered by the ingestion of wheat gluten and related proteins in genetically susceptible individuals. The CD is associated with human leucocyte antigen (HLA) genes particularly with HLA-DQ alleles encoding HLA-DQ2 and DQ8 proteins. To define risk and severity alleles for CD, a total of 120 definite CD patients and 100 healthy controls were...

Topics

Adolescent
Adult
Aged
Alleles
Celiac Disease
Child
Child, Preschool
Family Health
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
HLA-DQ beta-Chains
Humans
Infant
Iran
Male
Middle Aged

Source

Open in PubMed

Identifiers

PMID: 24917237
DOI: 10.1111/iji.12128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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