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Article

Metal ion-binding studies highlight important differences between flaviviral RNA polymerases.

Biochimica et biophysica acta - 1 Jan 2009

Bougie Isabelle, Bisaillon Martin

Abstract excerpt

West Nile virus (WNV) is a member of the Flaviviridae family which includes a number of important human pathogens. The WNV NS5 protein harbors an RNA-dependent RNA polymerase activity which is required both for replication and transcription of the viral genome. To extend our studies on the role of metal ions in the activity of flaviviral polymerases, we have used fluorescence spectroscopy, circular dichroism, and...

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Identifiers

PMID: 18930844
DOI: 10.1016/j.bbapap.2008.09.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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